INHIBITION OF NON-PRIMATE LENTIVIRUSES BY APOBEC3 CYTIDINE DEAMINASE

Jörg Zielonka
APOBEC3 (apolipoprotein B mRNA editing catalytic polypeptide 3 [A3]) proteins are an element of the intrinsic immunity of modern mammalia against retroviruses. The evolution of the A3 genes is characterized by an adaptive selection and a taxon-specific expansion and/or extinction. All A3 genes consist either of one zinc (Z)-coordinating domain (Z1, Z2 or Z3) or two Z-domains (Z2-Z1, Z2-Z2, Z2-Z3). While humans carry seven A3 genes, Equus caballus carries six and Felis catus four A3...
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.