Investigation of a NKG2D-dependent tumor immune escape mechanism of head and neck squamous cell carcinoma and proof of concept of a clinical intervention strategy

Sandra Weil
Natural killer cells are large granular lymphocytes of the innate immune system, which play an important role in the recognition and elimination of malignantly transformed and infected cells. The major activating NK cell receptor NKG2D, which is also expressed as co-stimulatory receptor on T cell subsets, is thereby a key modulator for tumor recognition and immune cell cytotoxicity. NKG2D recognizes several structurally related cellular ligands (MICA, MICB and ULBP1-6) commonly overexpressed on tumor cells. However,...
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