A system toxicology approach to investigate the impact of an acute exposure to cigarette smoke and electronic cigarette on human lung and oral in vitro

Anita Iskandar, Filippo Zanetti, Athanasios Kondylis, Florian Martin, Patrice Leroy, Shoaib Majeed, Sandro Steiner, Yang Xiang, Laura Ortega Torres, Keyur Trivedi, Emmanuel Guedj, Celine Merg, Stefan Frentzel, Nikolai Ivanov, Utkarsh Doshi, K. Lee, Willie McKinney Jr, Manuel Peitsch & Julia Hoeng
This study provides morphological and mechanistic insights into the impact on human lung and oral epithelium of the exposure to cigarette smoke and aerosols of electronic cigarettes. Human organotypic buccal and small lung airway cultures were exposed at the air-liquid interface to cigarette smoke and aerosols of different formulations of electronic cigarettes, namely "Test Mix" (flavours, nicotine, humectants), "Base" (nicotine, humectants) and "Carrier" (humectants). The acute impact of these test products on cellular morphology, toxicology...
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