Assessment of Acute THS 2.2 Aerosol Exposure in in vitro Human Nasal Epithelial Cultures

Anita Iskandar, Carole Mathis, Florian Martin, Patrice Leroy, Alain Sewer, Shoaib Majeed, Diana Kuehn, Keyur Trivedi, Davide Grandolfo, Maciej Cabanski, Emmanuel Guedj, Céline Merg, Stefan Frentzel, Nikolai Ivanov, Manuel Peitsch & Julia Hoeng
To assess the biological impact of 3R4F smoke and THS 2.2 aerosol, a series of five experimental repetitions was conducted. The repetition was performed to increase the robustness of the impact assessment. Nasal epithelial cultures were exposed to comparable doses of 3R4F smoke and THS 2.2 aerosol. In addition, a high dose of THS 2.2 was applied at a target nicotine concentration of 0.44 mg/L aerosol). Using the Vitrocell® Dilution/Distribution module, these specific nicotine concentrations...
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