Mechanisms of Anti-Obesity Effects of Capsaicin

Baskaran Thyagarajan
Obesity is a major metabolic disease. Currently, there are no effective strategies to counter obesity. Transient receptor potential vanilloid subfamily 1 (TRPV1), a non-selective cation channel protein expressed in metablically important tissues, has been pursued as a target to combat obesity. In our efforts to understand the mechanisms by which activation of TRPV1 by its selective agonist capsaicin counters obesity we discovered that mammalian white and brown adipose tissues (WAT and BAT, respectively) endgenously express...
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