Quantitative analysis of dynamic 18F-FDG PET/CT for measurement of lung inflammation

C Coello, M Fisk, D Mohan, FJ Wilson, AP Brown, MI Polkey, Ian Wilkinson, R Tal-Singer, PS Murphy, Joseph Cheriyan & RN Gunn
$\textbf{Background:}$ An inflammatory reaction in the airways and lung parenchyma, comprised mainly of neutrophils and alveolar macrophages, is present in some patients with chronic obstructive pulmonary disease (COPD). Thoracic fluorodeoxyglucose $^{18}$F-FDG) positron emission tomography (PET) has been proposed as a promising imaging biomarker to assess this inflammation. We sought to introduce a fully quantitative analysis method and compare this with previously published studies based on the Patlak approach using a dataset comprising $^{18}$F-FDG PET scans...

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