Cerebral autoregulation monitoring in acute traumatic brain injury: what’s the evidence?

Leanne Calviello, Joseph Donnelly, Frederick Zeiler, Eric Thelin, Piotr Smielewski & Marek Czosnyka
Cerebral autoregulation is conceptualized as a vascular self-regulatory mechanism within the brain. Controlled by elusive relationships between various biophysical processes, it functions to protect the brain against potential damages caused by sudden changes in cerebral perfusion pressures and flow. Following events such as traumatic brain injuries (TBI), autoregulation may be compromised, potentially leading to an unfavorable outcome. In spite of its complexity, autoregulation has been able to be quantified non-invasively within the neuro-critical care setting...
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