AKR1C3-mediated adipose androgen generation drives lipotoxicity in women with polycystic ovary syndrome

MW O'Reilly, P Kempegowda, M Walsh, AE Taylor, K Manolopoulos, JW Allwood, Robert Semple, D Hebenstreit, WB Dunn, JW Tomlinson & W Arlt
Context: Polycystic ovary syndrome (PCOS) is a prevalent metabolic disorder, occurring in up to 10% of women of reproductive age. PCOS is associated with insulin resistance and cardiovascular risk. Androgen excess is a defining feature of PCOS and has been suggested as causally associated with insulin resistance; however, mechanistic evidence linking both is lacking. We hypothesized that adipose tissue is an important site linking androgen activation and metabolic dysfunction in PCOS. Methods We performed a...
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