Risk Score Predicts High-Grade Prostate Cancer in DNA-Methylation Positive, Histopathologically Negative Biopsies

Neste Leander Van, Alan W Partin, Grant Stewart, Jonathan I Epstein, David J Harrison & Criekinge Wim Van
Background: Prostate cancer (PCa) diagnosis is challenging because efforts for effective, timely treatment of men with significant cancer typically result in over-diagnosis and repeat biopsies. The presence or absence of epigenetic aberrations, more specifically DNA-methylation of GSTP1, RASSF1 and APC, in histopathologically negative prostate core biopsies has resulted in an increased negative predictive value (NPV) of ~90% and thus could lead to a reduction of unnecessary repeat biopsies. Here, it is investigated whether, in methylation-positive...
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