Dynamic epigenetic changes to VHL occur with sunitinib in metastatic clear cell renal cancer.

Grant Stewart, T Powles, C Van Neste, A Meynert, F O'Mahony, A Laird, D Deforce, F Van Nieuwerburgh, G Trooskens, W Van Criekinge, T De Meyer & DJ Harrison
Background: Genetic intratumoral heterogeneity (ITH) hinders biomarker development in metastatic clear cell renal cancer (mccRCC). Epigenetic relative to genetic ITH or the presence of consistent epigenetic changes following targeted therapy in mccRCC have not been evaluated. The aim of this study was to determine methylome/genetic ITH and to evaluate specific epigenetic and genetic changes associated with sunitinib. Patients and methods: Multi-region DNA sampling performed on sequential frozen pairs of primary tumor tissue from 14 metastatic...

This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.