Cell-autonomous programming of rat adipose tissue insulin signalling proteins by maternal nutrition

Malgorzata Martin-Gronert, Denise Fernandez-Twinn, Martin Bushell, Kenneth Siddle & Susan Ozanne
Aims/hypothesis Individuals with low birth-weight have increased risk of developing type 2 diabetes mellitus in adulthood. This is associated with peripheral insulin resistance. Here we aim to determine whether changes in insulin signalling proteins in white adipose tissue (WAT) can be detected prior to the onset of impaired glucose tolerance, if these changes are cell autonomous and to identify underlying mechanisms involved. Methods 14-month-old male rat offspring, born to dams fed a standard protein (20%)...
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