An association between ICP-derived data and outcome in TBI patients: The role of sample size

Brenno Cabella, Joseph Donnelly, Danilo Cardim, Xiuyun Liu, Manuel Cabeleira, Piotr Smielewski, Christina Haubrich, Peter Hutchinson, Dong Joo Kim & Marek Czosnyka
${\bf Background:}$ Many demographic and physiological variables have been associated with outcome after TBI. However, with small sample sizes, making spurious inferences is possible. This paper explores the effect of sample sizes on statistical relationships between patient variables (both physiological and demographic) and outcome. ${\bf Methods:}$ Data from head-injured patients with monitored arterial blood pressure, intracranial pressure (ICP) and outcome assessed at 6 months were included in this retrospective analysis. A univariate logistic regression analysis...
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