Serum Endotoxins and Flagellin and Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort.

So Yeon Kong, Hao Quang Tran, Andrew T Gewirtz, Gail McKeown-Eyssen, Veronika Fedirko, Isabelle Romieu, Anne Tjønneland, Anja Olsen, Kim Overvad, Marie-Christine Boutron-Ruault, Nadia Bastide, Aurélie Affret, Tilman Kühn, Rudolf Kaaks, Heiner Boeing, Krasimira Aleksandrova, Antonia Trichopoulou, Maria Kritikou, Effie Vasilopoulou, Domenico Palli, Vittorio Krogh, Amalia Mattiello, Rosario Tumino, Alessio Naccarati, HB Bueno-De-Mesquita … & Mazda Jenab
BACKGROUND: Chronic inflammation and oxidative stress are thought to be involved in colorectal cancer development. These processes may contribute to leakage of bacterial products, such as lipopolysaccharide (LPS) and flagellin, across the gut barrier. The objective of this study, nested within a prospective cohort, was to examine associations between circulating LPS and flagellin serum antibody levels and colorectal cancer risk. METHODS: A total of 1,065 incident colorectal cancer cases (colon, n = 667; rectal, n...
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