Intake of Total and Subgroups of Fat Minimally Affect the Associations between Selected Single Nucleotide Polymorphisms in the PPARγ Pathway and Changes in Anthropometry among European Adults from Cohorts of the DiOGenes Study.

Sofus C Larsen, Lars Ängquist, Jane N Østergaard, Tarunveer S Ahluwalia, Karani S Vimaleswaran, Nina Roswall, Lotte M Mortensen, Birgit M Nielsen, Anne Tjønneland, Nicholas Wareham, Domenico Palli, Giovanna Masala, Wim HM Saris, Daphne L Van Der A, Jolanda MA Boer, Edith JM Feskens, Heiner Boeing, Marianne U Jakobsen, Ruth JF Loos, Thorkild IA Sørensen & Kim Overvad
BACKGROUND: Although the peroxisome proliferator-activated receptor γ (PPARγ) pathway is central in adipogenesis, it remains unknown whether it influences change in body weight (BW) and whether dietary fat has a modifying effect on the association. OBJECTIVES: We examined whether 27 single nucleotide polymorphisms (SNPs) within 4 genes in the PPARγ pathway are associated with the OR of being a BW gainer or with annual changes in anthropometry and whether intake of total fat, monounsaturated fat,...
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