The alternative splicing program of differentiated smooth muscle cells involves concerted non-productive splicing of post-transcriptional regulatorsMiriam Llorian, Clare Gooding, Nicolas Bellora, Martina Hallegger, Adrian Buckroyd, Xiao Wang, Dipen Rajgor, Melis Kayikci, Jack Feltham, Jernej Ule, Eduardo Eyras & Christopher Smith
Alternative splicing (AS) is a key component of gene expression programs that drive cellular differentiation. Smooth muscle cells (SMCs) are important in the function of a number of physiological systems; however, investigation of SMC AS has been restricted to a handful of events. We profiled transcriptome changes in mouse de-differentiating SMCs and observed changes in hundreds of AS events. Exons included in differentiated cells were characterized by particularly weak splice sites and by upstream binding...
This data repository is not currently reporting citations. For information on how your repository can report citations, please see our documentation.
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.