X-Box Binding Protein-1 Dependent Plasma Cell Responses Limit the Development of Atherosclerosis.

Andrew Sage, Meritxell Nus, J Bagchi Chakraborty, Dimitrios Tsiantoulas, Stephen Newland, AJ Finigan, L Masters, CJ Binder & Ziad Mallat
RATIONALE: Diverse B cell responses and functions may be involved in atherosclerosis. Protective antibody responses, such as those against oxidized lipid epitopes, are thought to mainly derive from T cell-independent innate B cell subsets. In contrast, both pathogenic and protective roles have been associated with T cell-dependent antibodies, and their importance in both humans and mouse models is still unclear. OBJECTIVE: To specifically target antibody production by plasma cells and determine the impact on atherosclerotic...

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