Enantioselective Copper-Catalyzed Arylation-driven Semi-Pinacol Rearrangement of Allylic Alcohols with Diaryliodonium Salts

Daniel Lukamto & Matthew Gaunt
A copper-catalyzed enantioselective arylative semi-pinacol rearrangement of allylic alcohols using diaryliodonium salts is reported. Chiral Cu(II)-bisoxazoline catalysts initiate an electrophilic alkene arylation, triggering a 1,2-alkyl migration to afford a range of non-racemic spirocyclic ketones with high yields, diastero- and enantioselectivities.
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