Lifetime use of psychiatric medications and cognition at 43 years of age in schizophrenia in the Northern Finland Birth Cohort 1966

Peter Jones, AP Hulkko, Graham Murray, J Moilanen, M Haapea, I Rannikko, Jennifer Helen Barnett, S Huhtaniska, MK Isohanni, H Koponen, E Jääskeläinen & J Miettunen
$\textbf{Background:}$ Higher lifetime antipsychotic exposure has been associated with poorer cognition in schizophrenia. The cognitive effects of adjunctive psychiatric medications and lifetime trends of antipsychotic use remain largely unclear. We aimed to study how lifetime and current benzodiazepine and antidepressant medications, lifetime trends of antipsychotic use and antipsychotic polypharmacy are associated with cognitive performance in midlife schizophrenia. $\textbf{Methods:}$ Sixty participants with DSM-IV schizophrenia from the Northern Finland Birth Cohort 1966 were examined at 43 years...
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