Hi-C as a tool for precise detection and characterisation of chromosomal rearrangements and copy number variation in human tumours

Louise Harewood, K Kishore, Eldridge, MD, S Wingett, D Pearson, S Schoenfelder, Vincent Collins & P Fraser
Chromosomal rearrangements occur constitutionally in the general population and somatically in the majority of cancers. Detection of balanced rearrangements, such as reciprocal translocations and inversions, is troublesome, which is particularly detrimental in oncology where rearrangements play diagnostic and prognostic roles. Here we describe the use of Hi-C as a tool for detection of both balanced and unbalanced chromosomal rearrangements in primary human tumour samples, with the potential to define chromosome breakpoints to bp resolution. In...
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