Sticky swinging arm dynamics: studies of an acyl carrier protein domain from the mycolactone polyketide synthase

S Vance, O Tkachenko, B Thomas, M Bassuni, Hui Hong, Daniel Nietlispach & Richard Broadhurst
Type I modular polyketide synthases (PKSs) produce polyketide natural products by passing a growing acyl substrate chain between a series of enzyme domains housed within a gigantic multifunctional polypeptide assembly. Throughout each round of chain extension and modification reactions, the substrate stays covalently linked to an acyl carrier protein (ACP) domain. Here we report on the solution structure and dynamics of an ACP domain excised from MLSA2, module 9 of the PKS system that constructs...
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