Using DTI to assess white matter microstructure in cerebral small vessel disease (SVD) in multicentre studies

ID Croall, V Lohner, B Moynihan, U Khan, A Hassan, John O'Brien, RG Morris, Daniel Tozer, VC Cambridge, K Harkness, DJ Werring, AM Blamire, GA Ford, TR Barrick & Hugh Markus
Diffusion tensor imaging (DTI) metrics such as fractional anisotropy (FA) and mean diffusivity (MD) have been proposed as clinical trial markers of cerebral small vessel disease (SVD) due to their associations with outcomes such as cognition. However, studies investigating this have been predominantly single-centre. As clinical trials are likely to be multisite, further studies are required to determine whether associations with cognition of similar strengths can be detected in a multicentre setting. One hundred and...

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