Decoupled Associative and Dissociative Processes in Strong yet Highly Dynamic Host-Guest Complexes.

Eric A Appel, Frank Biedermann, Dominique Hoogland, Jesús Del Barrio, Max D Driscoll, Sam Hay, David Wales & Oren Scherman
Kinetics and thermodynamics in supramolecular systems are intimately linked, yet both are independently important for application in sensing assays and stimuli-responsive switching/self-healing of materials. Host-guest interactions are of particular interest in many water-based materials, sensing and drug delivery applications. Herein we investigate the binding dynamics of a variety of electron-rich aromatic moieties forming hetero-ternary complexes with the macrocycle cucurbit[8]uril (CB[8]) and an auxiliary guest, dimethyl viologen, with high selectivity and equilibrium binding constants (Keq up...
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