Hypoxia upregulates neutrophil degranulation and potential for tissue injury.

K Hoenderdos, Katharine Lodge, RA Hirst, C Chen, SGC Palazzo, A Emerenciana, Charlotte Summers, A Angyal, L Porter, JK Juss, C O'Callaghan, Edwin Chilvers & AM Condliffe
Background. The inflamed bronchial mucosal surface is a profoundly hypoxic environment. Neutrophilic airway inflammation and neutrophil-derived proteases have been linked to disease progression in conditions such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF), but the effects of hypoxia on potentially harmful neutrophil functional responses such as degranulation are unknown. Methods and Results. Following exposure to hypoxia (0.8% oxygen, 3 kPa for 4 hours) neutrophils stimulated with inflammatory agonists (granulocyte-macrophage activating factor (GM-CSF)...
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