HCMV activation of ERK-MAPK drives a multi-factorial response promoting the survival of infected myeloid progenitors

V Kew, Mark Wills & M Reeves
Viral binding and entry provides the first trigger of a cell death response and thus how human cytomegalovirus (HCMV) evades this - particularly during latent infection where a very limited pattern of gene expression is observed - is less well understood. It has been demonstrated that the activation of cellular signalling pathways upon virus binding promotes the survival of latently infected cells by the activation of cell encoded anti-apoptotic responses. In CD34+ cells, a major...
1 citation reported since 2018
published in 2017

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