Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program

JP Sundberg, SS Dadras, KA Silva, VE Kennedy, G Garland, S Murray, BA Sundberg, Paul Schofield & CH Pratt
The International Knockout Mouse Consortium was formed in 2007 to inactivate (“knockout”) all protein-coding genes in the mouse genome in embryonic stem cells. Production and characterization of these mice, now underway, has generated and phenotyped 3,100 strains with knockout alleles. Skin and adnexa diseases are best defined at the gross clinical level and by histopathology. Representative retired breeders had skin collected from the back, abdomen, eyelids, muzzle, ears, tail, and lower limbs including the nails....
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