Multigenerational analysis of sex-specific phenotypic differences at midgestation caused by abnormal folate metabolism

N Padmanabhan, J Rakoczy, M Kondratowicz, Katerina Menelaou, Georgina Blake & Erica Watson
The exposure to adverse environmental conditions (e.g., poor nutrition) may lead to increased disease risk in an individual and their descendants. In some cases, the results may be sexually dimorphic. A range of phenotypes has been associated with deficiency in or defective metabolism of the vitamin folate. However, the molecular mechanism linking folate metabolism to development is still not well defined nor is it clear whether phenotypes are sex-specific. The enzyme methionine synthase reductase (MTRR)...
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