Genomics of lipid metabolism: Identifying novel causal pathways and new therapeutic targets for reducing risk of coronary heart disease

Eric Harshfield, D Stacey, Dirk Paul, Albert Koulman, Angela Wood, Adam Butterworth, EB Fauman, Julian Griffin, John Danesh & D Saleheen
Coronary heart disease (CHD) is one of the leading causes of death worldwide; mortality rates are expected to continue to rise over the coming decades. Circulating lipids have been shown to be strongly and linearly associated with risk of CHD; however, despite considerable efforts to demonstrate causality, available evidence is conflicting and insufficient. Study of the underlying metabolic pathways implicated in the association between lipids and CHD would help to disentangle and elucidate these complex...
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