Permeability transition in human mitochondria persists in the absence of peripheral stalk subunits of ATP synthase

Jiuya He, Joseph Carroll, S Ding, Ian Fearnley & John Walker
The opening of a non-specific channel, known as the permeability transition pore (PTP), in the inner membranes of mitochondria, can be triggered by calcium ions, leading to swelling of the organelle, disruption of the inner membrane and ATP synthesis, and cell death. Pore opening can be inhibited by cyclosporin A mediated via cyclophilin D. It has been proposed that the pore is associated with the dimeric ATP synthase, and that the OSCP (oligomycin sensitivity conferral...

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