Optoacoustic detection of early therapy-induced tumor cell death using a targeted imaging agent

B Xie, Michal Tomaszewski, Andre Neves, S Ros, D Hu, S McGuire, S Mullins, D Tice, R Sainson, Sarah Bohndiek, R Wilkinson & Kevin Brindle
Purpose: The development of new treatments and their deployment in the clinic may be assisted by imaging methods that allow an early assessment of treatment response in individual patients. The C2A domain of Synaptotagmin-I (C2Am), which binds to the phosphatidylserine (PS) exposed by apoptotic and necrotic cells, has been developed as an imaging probe for detecting cell death. Multispectral optoacoustic tomography (MSOT) is a real-time and clinically applicable imaging modality that was used here with...
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