Investigation of correlates of protection against pharyngeal carriage of Neisseria meningitidis genogroups W and Y in the African meningitis belt

Laura Cooper, RM Boukary, R Borrow, A Aseffa, W Mihret, JM Collard, D Doumagoum, A Hodgson, C Sokhna, B Omotar, S Sow, SL Quaye, K Diallo, O Manigart, MCJ Maiden, H Findlow, R Borrow, JM Stuart, BM Greenwood & Caroline Trotter
BACKGROUND: Serum bactericidal antibody titres that correlate with protection against invasive meningococcal disease have been characterised. However, titres that are associated with protection against acquisition of pharyngeal carriage of Neisseria meningitidis are not known. METHODS: Sera were obtained from the members of a household in seven countries of the African meningitis belt in which a pharyngeal carrier of N. meningitidis had been identified during a cross-sectional survey. Serum bactericidal antibody titres at baseline were compared...

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