Second-order estimating equations for clustered current status data from family studies using response-dependent sampling

Yujie Zhong & RJ Cook
Studies about the genetic basis for disease are routinely conducted through family studies under response-dependent sampling in which affected individuals called probands are sampled from a disease registry, and their respective family members (non-probands) are recruited for study. The extent to which the dependence in some feature of the disease process (e.g. presence, age of onset, severity) varies according to the kinship of individuals, reflects the evidence of a genetic cause for disease. When the...

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