Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions

D Shungin, WQ Deng, TV Varga, Jian'an Luan, E Mihailov, A Metspalu, GIANT Consortium, AP Morris, Nita Forouhi, C Lindgren, PKE Magnusson, NL Pedersen, G Hallmans, AY Chu, AE Justice, M Graff, TW Winkler, LM Rose, Claudia Langenberg, LA Cupples, PM Ridker, Nicholas Wareham, Kenneth Ong, RJF Loos, DI Chasman … & PW Franks
Phenotypic variance heterogeneity across genotypes at a single nucleotide polymorphism (SNP) may reflect underlying gene-environment (G×E) or gene-gene interactions. We modeled variance heterogeneity for blood lipids and BMI in up to 44,211 participants and investigated relationships between variance effects (P$_v$), G×E interaction effects (with smoking and physical activity), and marginal genetic effects (P$_m$). Correlations between P$_v$ and P$_m$ were stronger for SNPs with established marginal effects (Spearman's ρ = 0.401 for triglycerides, and ρ =...
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