Investigation of a Cluster of ST22 MRSA Transmission in a Community Setting

Michelle Toleman, B Blane, Ewan Harrison, F Coll, Julian Parkhill, N Brown & SJ Peacock
BACKGROUND: Whole-genome sequencing (WGS) has typically been used to confirm or refute hospital/ward outbreaks of methicillin-resistant Staphylococcus aureus (MRSA) identified through routine practice. However, appropriately targeted WGS strategies that identify routinely ‘undetectable’ transmission remains the ultimate aim. METHODS: WGS of MRSA isolates sent to a regional microbiological laboratory was performed as part of a 12-month prospective observational study. Phylogenetic analyses identified a genetically-related cluster of E-MRSA15 isolated from patients registered to the same General Practice...
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