Modeling of axonal endoplasmic reticulum network by spastic paraplegia proteins

B Yalçın, Lu Zhao, M Stofanko, NC O'Sullivan, ZH Kang, A Roost, MR Thomas, S Zaessinger, O Blard, AL Patto, Anood Sohail, V Baena, M Terasaki & Charles O'Kane
Axons contain a smooth tubular endoplasmic reticulum (ER) network that is thought to be continuous with ER throughout the neuron; the mechanisms that form this axonal network are unknown. Mutations affecting reticulon or REEP proteins, with intramembrane hairpin domains that model ER membranes, cause an axon degenerative disease, hereditary spastic paraplegia (HSP). We show that Drosophila axons have a dynamic axonal ER network, which these proteins help to model. Loss of HSP hairpin proteins causes...
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