Determination of the physiological and pathological roles of E2F3 in adult tissues

I Gamper, Deborah Burkhart, MB Bywater, D Garcia, Catherine Wilson, PA Kreuzaler, MJ Arends, YW Zheng, A Perfetto, Trevor Littlewood & Gerard Evan
While genetically engineered mice have made an enormous contribution towards the elucidation of human disease, it has hitherto not been possible to tune up or down the level of expression of any endogenous gene. Here we describe compound genetically modified mice in which expression of the endogenous E2f3 gene may be either reversibly elevated or repressed in adult animals by oral administration of tetracycline. This technology is, in principle, applicable to any endogenous gene, allowing...
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