Mendelian Randomisation study of the influence of eGFR on coronary heart disease.

Pimphen Charoen, Dorothea Nitsch, Jorgen Engmann, Tina Shah, Jonathan White, Delilah Zabaneh, Barbara Jefferis, Goya Wannamethee, Peter Whincup, Cassidy Amy Mulick, Tom Gaunt, Ian Day, Stela McLachlan, Jacqueline Price, Meena Kumari, Mika Kivimaki, Eric Brunner, Claudia Langenberg, Yoav Ben-Shlomo, Aroon Hingorani, John Whittaker, Casas Juan Pablo, Frank Dudbridge & Consortium UCLEB
Impaired kidney function, as measured by reduced estimated glomerular filtration rate (eGFR), has been associated with increased risk of coronary heart disease (CHD) in observational studies, but it is unclear whether this association is causal or the result of confounding or reverse causation. In this study we applied Mendelian randomisation analysis using 17 genetic variants previously associated with eGFR to investigate the causal role of kidney function on CHD. We used 13,145 participants from the...
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