Synthesis, in Vitro Evaluation, and Radiolabelling of Fluorinated Puromycin Analogues: Potential Candidates for PET Imaging of Protein SynthesisHM Betts, Selena Milicevic Sephton, C Tong, RO Awais, PJ Hill, AC Perkins & Franklin Aigbirhio
There is currently no ideal radiotracer for imaging protein synthesis rate (PSR) by positron emission tomography (PET). Existing fluorine-18 labelled amino acid-based radiotracers predominantly visualize amino acid transporter processes, and in many cases they are not incorporated into nascent proteins at all. Others are radiolabelled with the short half-life positron emitter carbon-11 which is rather impractical for many PET centers. Based on the puromycin (6) structural manifold, a series of 10 novel derivatives of 6...
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