Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis.

Xiaoting Wu, Angeleen Fleming, Thomas Ricketts, Mariana Pavel, H Virgin, Fiona Menzies & David Rubinsztein
Autophagy is a conserved, intracellular, lysosomal degradation pathway. While mechanistic aspects of this pathway are increasingly well defined, it remains unclear how autophagy modulation impacts normal physiology. It is, however, becoming clear that autophagy may play a key role in regulating developmental pathways. Here we describe for the first time how autophagy impacts stem cell differentiation by degrading Notch1. We define a novel route whereby this plasma membrane-resident receptor is degraded by autophagy, via uptake...
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