CARD9 negatively regulates NLRP3-induced IL-1β production upon Salmonella infection of macrophages

Milton Pereira, Panagiotis Tourlomousis, John Wright, Tom Monie & Clare Bryant
Interleukin 1b (IL-1b) is a pro-inflammatory cytokine required for host control of bacterial infections. Its production must be tightly regulated to prevent excessive inflammation. Here we identify a surprising negative regulatory role for caspase recruitment domain-containing protein 9 (CARD9), a protein associated with induction of pro-inflammatory cytokines by fungi, on IL-1b production during bacterial infection. CARD9 negatively regulates IL-1β production in response to activation of the nucleotide oligomerization domain receptor pyrin-domain containing protein 3 (NLRP3)...
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