Events in Early Life are Associated with Female Reproductive Ageing: A UK Biobank Study

Katherine S Ruth, John Perry, William E Henley, David Melzer, Michael N Weedon & Anna Murray
The available oocyte pool is determined before birth, with the majority of oocytes lost before puberty. We hypothesised that events occurring before birth, in childhood or in adolescence (‘early-life risk factors’) could influence the size of the oocyte pool and thus the timing of menopause. We included cross-sectional data from 273,474 women from the UK Biobank, recruited in 2006–2010 from across the UK. We analysed the association of early menopause with events occurring before adulthood...
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