A class of human exons with predicted distant branch points revealed by analysis of AG dinucleotide exclusion zones

Clare Gooding, F Clark, MC Wollerton, SN Grellscheid, H Groom & Christopher Smith
Background: The three consensus elements at the 3' end of human introns-the branch point sequence, the polypyrimidine tract, and the 3' splice site AG dinucleotide-are usually closely spaced within the final 40 nucleotides of the intron. However, the branch point sequence and polypyrimidine tract of a few known alternatively spliced exons lie up to 400 nucleotides upstream of the 3' splice site. The extended regions between the distant branch points (dBPs) and their 3' splice...
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