Circulating granulocyte lifespan in compensated alcohol-related cirrhosis: a pilot study

Jonathan R Potts, Neda Farahi, Sarah Heard, Edwin Chilvers, Sumita Verma & Adrien M Peters
Although granulocyte dysfunction is known to occur in cirrhosis, in vivo studies of granulocyte lifespan have not previously been performed. The normal circulating granulocyte survival half-time (G - $t_{½}$), determined using indium-111 ($^{111}$In)-radiolabeled granulocytes, is ~7 h. In this pilot study, we aimed to measure the in vivo G - $t_{½}$ in compensated alcohol-related cirrhosis. Sequential venous blood samples were obtained in abstinent subjects with alcohol-related cirrhosis over 24 h post injection (PI) of minimally...
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