The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization.J He, C-C Mao, Aurelio Reyes, Hiroshi Sembongi, M Di Re, C Granycome, AB Clippingdale, Ian Fearnley, M Harbour, Alan Robinson, S Reichelt, JN Spelbrink, John Walker & IJ Holt
Many copies of mammalian mitochondrial DNA contain a short triple-stranded region, or displacement loop (D-loop), in the major noncoding region. In the 35 years since their discovery, no function has been assigned to mitochondrial D-loops. We purified mitochondrial nucleoprotein complexes from rat liver and identified a previously uncharacterized protein, ATAD3p. Localization studies suggested that human ATAD3 is a component of many, but not all, mitochondrial nucleoids. Gene silencing of ATAD3 by RNA interference altered the...
This data repository is not currently reporting citations. For information on how your repository can report citations, please see our documentation.
This data repository is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.