The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization.J He, C-C Mao, Aurelio Reyes, Hiroshi Sembongi, M Di Re, C Granycome, AB Clippingdale, Ian Fearnley, M Harbour, Alan Robinson, S Reichelt, JN Spelbrink, John Walker & IJ Holt
Many copies of mammalian mitochondrial DNA contain a short triple-stranded region, or displacement loop (D-loop), in the major noncoding region. In the 35 years since their discovery, no function has been assigned to mitochondrial D-loops. We purified mitochondrial nucleoprotein complexes from rat liver and identified a previously uncharacterized protein, ATAD3p. Localization studies suggested that human ATAD3 is a component of many, but not all, mitochondrial nucleoids. Gene silencing of ATAD3 by RNA interference altered the...
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