The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization.

J He, C-C Mao, Aurelio Reyes, Hiroshi Sembongi, M Di Re, C Granycome, AB Clippingdale, Ian Fearnley, M Harbour, Alan Robinson, S Reichelt, JN Spelbrink, John Walker & IJ Holt
Many copies of mammalian mitochondrial DNA contain a short triple-stranded region, or displacement loop (D-loop), in the major noncoding region. In the 35 years since their discovery, no function has been assigned to mitochondrial D-loops. We purified mitochondrial nucleoprotein complexes from rat liver and identified a previously uncharacterized protein, ATAD3p. Localization studies suggested that human ATAD3 is a component of many, but not all, mitochondrial nucleoids. Gene silencing of ATAD3 by RNA interference altered the...
This data center is not currently reporting usage information. For information on how your repository can submit usage information, please see our documentation.
We found no citations for this text. For information on how to provide citation information, please see our documentation.