The influence of dopamine on cognitive flexibility is mediated by functional connectivity in young but not older adults

Anne Berry
Dopaminergic signaling in striatum is strongly implicated in executive functions including cognitive flexibility. However, there is a paucity of multimodal research in humans defining the nature of relationships between endogenous dopamine, striatal network activity, and cognition. Here, we measured dopamine synthesis capacity in young and older adults using the PET tracer 6-[18F]fluoro-L-m-tyrosine, and examined its relationship with cognitive performance and functional connectivity during an fMRI study of task switching. Aging is associated with alteration in...
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2 downloads reported since publication in 2018.

These counts follow the COUNTER Code of Practice, meaning that Internet robots and repeats within a certain time frame are excluded.
What does this mean?