Serotonin release measured in the human brain: a PET study with [

David Erritzoe, Abhishekh H Ashok, Graham E Searle, Alessandro Colasanti, Samuel Turton, Yvonne Lewis, Mickael Huiban, Sara Moz, Jan Passchier, Azeem Saleem, John Beaver, Anne Lingford-Hughes, David J Nutt, Oliver D Howes, Roger N Gunn, Gitte M Knudsen & Eugenii A Rabiner
Positron emission tomography (PET) enables non-invasive estimation of neurotransmitter fluctuations in the living human brain. While these methods have been applied to dopamine and some other transmitters, estimation of 5-hydroxytryptamine (5-HT; Serotonin) release has proved to be challenging. Here we demonstrate the utility of the novel 5-HT2A receptor agonist radioligand, [ C]CIMBI-36, and a d-amphetamine challenge to evaluate synaptic 5-HT changes in the living human brain. Seventeen healthy male volunteers received [ C]CIMBI-36 PET scans...
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