Blood-based systems biology biomarkers for next-generation clinical trials in Alzheimer's disease .

Harald Hampel, Andrea Vergallo, Mohammad Afshar, Leyla Akman-Anderson, Joaquín Arenas, Norbert Benda, Richard Batrla, Karl Broich, Filippo Caraci, A Claudio Cuello, Enzo Emanuele, Marion Haberkamp, Steven J Kiddle, Alejandro Lucía, Mark Mapstone, Steven R Verdooner, Janet Woodcock & Simone Lista
Alzheimer's disease (AD)-a complex disease showing multiple pathomechanistic alterations-is triggered by nonlinear dynamic interactions of genetic/epigenetic and environmental risk factors, which, ultimately, converge into a biologically heterogeneous disease. To tackle the burden of AD during early preclinical stages, accessible blood-based biomarkers are currently being developed. Specifically, next-generation clinical trials are expected to integrate positive and negative predictive blood-based biomarkers into study designs to evaluate, at the individual level, target druggability and potential drug resistance mechanisms....
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