A Latent Variable Phenotype for the Dementia Diagnosis and Biomarker Selection in TBI

Ray Palmer
Although Traumatic Brain Injury (TBI) has been associated with 1) cognitive impairment, 2) the clinical diagnosis of ?Alzheimer?s Disease (AD)?, and 3) AD-related neuropathology, all are vulnerable to measurement error, and none are both necessary to and sufficient for the dementia of AD (DAD). Before the field can advance to biomarker selection and treatment, ?dementia? and ?Mild Cognitive Impairment (MCI)? in the setting of TBI must both be more precisely defined. Objective/Hypothesis: We will construct...
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