Autoantibody biomarker discovery in primary open angle glaucoma using serological proteome analysis (SERPA)

Vanessa M. Beutgen, Natarajan Perumal, Norbert Pfeiffer & Franz-Hermann Grus
Glaucoma is an optic neurological disorder and the leading cause of irreversible blindness worldwide worldwide, with primary open angle glaucoma (POAG) as its most prevalent form. An early diagnosis of of the disease is crucial to prevent loss of vision. Mechanisms behind glaucoma pathogenesis are not completely understood, but disease related alterations in the serological autoantibody profile indicate indicate an immunologic component. These changes in immunoreactivity may serve as potential biomarkers biomarkers for glaucoma diagnostics....
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