Neuroprotective and neuroregenerative effects of CRMP-5 on retinal ganglion cells in an experimental in vivo and in vitro model of glaucoma

Jasmin Lauzi, Fabian Anders, Hanhan Liu, Norbert Pfeiffer, Franz-Hermann Grus, Solon Thanos, Stefan Arnhold & Verena Prokosch-Willing
Purpose To analyze the potential neuro-protective and neuro-regenerative effects of Collapsin-response response-mediator-protein-5 (CRMP-5) on retinal ganglion cells (RGCs) using in vitro and in vivo animal animal models of glaucoma. Methods Elevated intraocular pressure (IOP) was induced in adult female female Sprague-Dawley (SD) rats by cauterization of three episcleral veins. Changes in CRMP-5 expression expression within the retinal proteome were analyzed via label-free mass spectrometry. In vitro, retinal explants were cultured under elevated pressure (60 mmHg)...
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