Patient-derived cancer cells to dissect the molecular basis of treatment response in primary liver cancer: a mechanistic and functional approach

Darko Castven
Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) are two major types of primary liver cancers (PLC), ranking among the deadliest cancers worldwide with poor overall survival rates. Lack of clinical symptoms and effective biomarkers for early detection are main causes of late diagnosis. Despite identification of several potentially drugable targets and subsequent development of next-generation targeted therapies, translation of these findings into clinical practice remains challenging. Further, there is a lack of models that truly and...
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